Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures.Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix.We propose that this increased stiffness positively feeds back on the contractile activities of myofib
In industrial settings and processes, yeasts may face multiple adverse environmental conditions.These include exposure to non-optimal temperatures or pH, osmotic stress, and deleterious concentrations of diverse inhibitory compounds.These toxic chemicals may result from the desired accumulation of added-value bio-products, yeast metabolism, or be p
Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treatments and prognosis.The Neuroligin-3 (NL3)R451C mouse model of ASD has a heightened aggressive phenotype, however the biological mechanisms underlying this behavior are unknown.It is well established that NL3R451C mice h
The title complex, [Fe(C6H4N5)2(H2O)2], was synthesized by the reaction of ferrous sulfate with mini-dresses 5-(2-pyridyl)-2H-tetrazole (HL).The FeII atom, located on a crystallographic center of inversion, is coordinated by four N-atom donors from two planar trans-related deprotonated L ligands and two O atoms from two axial water molecules in a d
Abstract Background Dihydropyrimidine dehydrogenase (DPD), is the initial and rate-limiting enzyme in the catabolic pathway of pyrimidines.Deleterious variants in the DPYD gene cause DPD deficiency, a rare autosomal recessive disorder.The clinical spectrum of affected individuals is wide ranging from asymptomatic to severely affected patients prese